Artificial Sweetener Sucralose May Lead to Metabolic Syndrome

In a still unfinished project I had been talking about sugar and also artificial sweeteners. “I consider the idea of sweeteners nonsense. / It is not a matter of looking for alternatives to sugars, which then also turn out to be problematic.” [1] If artificial sweeteners, which contain no calories, are used to fatten pigs than we should be alerted.

There has been a study at the 2018 Endocrine Society’s Annual Meeting in Miami. N. Kundu and colleagues presented [2]: “Sucralose Promotes Metabolic Dysregulation and Intracellular ROS [reactive oxygen species] Accumulation”. Conclusion: “Analysis of in vitro human MSCs [mesenchymal stem cells] exposed to sucralose, data along with subjects’ fat biopsy sample analysis data from consumers and subject’s biochemistry indicates that sucralose promotes metabolic dysregulation (by increased glucose uptake, inflammation and adipogenesis) which is associated with increased intra-cellular ROS accumulation and high TG. This effect appears to be more evident in obese rather than non-obese subjects. …”

J. Suez and colleagues published in 2014 [3]: “Artificial sweeteners induce glucose intolerance by altering the gut microbiota”. In conclusion, the authors “link NAS [non-caloric artificial sweeteners] consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.”

What’s the gist? Stay away from (sugar) sweetened and artificially sweetened beverages and foods.

Links: 

[1] http://rheumatologe.blogspot.de/2017/06/diet-for-urban-troglodyte-01-sugar.html

[2] http://www.abstractsonline.com/pp8/#!/4482/presentation/8752

[3] http://www.nature.com/articles/nature13793

.