Is Calcium Pyrophosphate Deposition Associated with Vitamin D Deficiency?

There are some know risk factors for calcium pyrophosphate deposition like gout, hyperparathyroidism, loop diuretics. osteoarthritis, rheumatoid arthritis, and more. Calcium pyrophosphate deposition is causing the second most common form of crystal-associated arthropathy. Sophia Li and colleagues researched the question, if calcium pyrophosphate deposition is associated with vitamin d deficiency. The study leads to the conclusion that vitamin D deficiency may be another metabolic abnormality associated with CPPD.


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Is Calcium Pyrophosphate Deposition Associated with Vitamin D Deficiency?
Sophia Li1, Joshua Baker1, Janet E. Dinnella1, Gilda M. Clayburne2, Joseph R. Perno2, H. Ralph Schumacher2 and Sally W. Pullman-Mooar2. 1
University of Pennsylvania, Philadelphia, PA, 2VA Medical Center, Philadelphia, PA
Conclusion: Our study suggests that vitamin D deficiency may be another metabolic abnormality associated with CPPD. Strengths of this study include the crystal proven diagnosis and blinded assessment of synovial fluid. Limitations of this study include the small numbers which limits controlling for all potential confounders. Further study is warranted to better understand the implications of vitamin D deficiency in CPPD.