There has been a study on
fibromyalgia and spironolactone in the Scandinavian Journal of
Pain by H. Wernze and Th. Herdegen: "Long-term efficacy of on pain, mood, and quality of
life in women with fibromyalgia: An observational case series." Quite a
strange study: no control group, no randomization, no end point, and moreover
only a statistical analysis of responders. Perhaps I ask for too much, but I
think putting patients under drugs should result in more than an "observational
case series". I'm surprised that the authors got a positive ruling by
their ethics committee. The authors concluded: "Fifteen of 31 women with otherwise treatment-resistant
FMS experienced a number of prolonged beneficial effects from spironolactone on
their complex pain-condition." They discussed: "Well-controlled,
double-blind, and randomised trials are necessary to confirm our potentially
very important observations." Very humble, indeed. They also discussed:
"The high rate of non-responsive patients underlines that FMS may
represent several subgroups." In this kind of studies you often find a
hint at subgroups, but these haven't been defined yet. Perhaps it would be
better, to define subgroups before starting giving drugs to patients.
I don't think that there
will be coming much out of spironolactone in treating fibromyalgia. But I can't
deny that there is this observation. If spironolactone in fibromyalgia is to be
studied further, please only in a proper study.
PS.: PubMed didn't list any study, when I searched for
it:
This is not a clinical study but a case series of a GP.
ReplyDeleteThe authors have put 31 patients under a drug, that hasn't been approved as a therapy for fibromyagia. One could observe a couple of patients, who take the drug because of another disease, but 31 patients is already such a large group that this fact alone raises ethical concerns.
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