Anja Strangfeld and colleagues looked into the improvement of fatigue in patients under therapy as repeorted to the German biologics register RABBIT. Fatigue significantly affects physical health and limits social live of patients with rheumatoid arthritis. TNF leads to prolonged brain activity upon nociceptive stimulation. TNF-inhibition rapidly reverses this effect without being linked primarily to anti-inflammatory effects of the drugs. Biologic agents improved fatigue significantly more frequently than conventional DMARDs.
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Impact of Different Biologic Agents on the Improvement of Fatigue.
Anja Strangfeld1, Matthias Schneider2, Jörg Kaufmann3, Andreas Krause4, Angela Zink5 and Joachim Listing6.
1Deutsches Rheumaforschungszentrum, Berlin, Germany, 2Heinrich-Heine-University, Duesseldorf, Germany,
3Rheumatologist, Ludwigsfelde, Germany, 4Immanuel Krankenhaus Berlin-Buch, Berlin, Germany, 5Deutsches Rheumaforschungszentrum and Charité University Medicine, Berlin, Germany, 6German Rheumatism Research Centre, Berlin, Germany
Conclusion: Treatment with a biologic agent improved fatigue significantly more frequently than with a conventional DMARD. This finding is supported by experimental research in which Hess et al. observed that blocking TNF does not only have anti-inflammatory effects but also an impact on processes in the CNS.
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