Saturday, February 13, 2010

NSAIDs - a German observation

I've made a strange observation, quite a lot of both patients and physicians think that ibuprofene has less side effects than diclofenac, but think that diclofenac is the more potent NSAID.
I think it has something to do with dosage. Ibuprofene comes in a multitude of dosages 200, 300, 400, 600, 800 mgs and others. Diclofenac is mostly prescribed in the 50 mg or 75 mgs dosage, though other dosages exist as well. With 150 mgs diclofenac being the upper dosage, you reach this level with 2x75 mgs. If you start with 3x300 mgs ibuprofene, you'll have a long way to reach 2400 mgs, which is the upper level.
All in all diclofenac and ibuprofene have an equal share of side effect or efficacy given at comparable dosages.
If one has to take aspirin for vascular reason, diclofenac is the better choice, as ibuprofene which couteract the effect of aspirin.

PS.: This is internet and not a medical practice - don't change your medication unless you've asked your physician.

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