There has been one
publication on ABT-122 at the ACR 2015 Annual Meeting in San Francisco. ABT-122
is an anti-TNF/IL-17 Dual Variable Domain immunoglobulin (DVD-Ig™). It had been
"demonstrated that dual neutralization of TNF and IL-17 provides greater
efficacy than blocking either cytokine alone in mouse collagen induced
arthritis". But we already know, that for instance secukinumab (an
anti-IL-17a MAB) did not achieve the primary endpoint (ACR20) in patients with
rheumatoid arthritis. So, from the beginning I’m very sceptical. But let’s look
at the study.
Roy Fleischmann and colleagues
presented: “Safety, Tolerability, and Pharmacodynamics of ABT-122, a Dual TNF-
and IL-17-Targeted Dual Variable Domain (DVD)-IgTM in Subjects with Rheumatoid
Arthritis”. Background/Purpose: […] ABT-122 is […] is hypothesized to provide
greater clinical responses in patients with RA.” Conclusion: “ABT-122
demonstrated a well tolerated safety profile in subjects with RA through 8 weeks
of dosing up to 3 mg/kg, […] decreases in these chemokines [CXCL9, CXCL10, and
CCL23] indicate that ABT-122 rapidly modulates potential pathophysiologic
pathways in RA patients, with evidence for persistent effects after cessation
of dosing. These results suggest that
dual neutralization of TNF and IL-17 may provide an opportunity to control
inflammation and its clinical manifestations in RA subjects and in other
immune-mediated inflammatory diseases.” Thin ice!
I think the first step in
convincing me would be testing ABT-122 against a TNF-inhibitor. As ABT-122 comes
from AbbVie, testing against Humira shouldn’t be a problem. Until then, IL-17
in ABT-122 may be nothing more than a pinch of cinnamon in the coffee, which changes
the flavour but not the caffeine content.
References:
Fleischmann R, Wagner F,
Kivitz AJ, Mansikka HT, Khan N, Liu J, Gagnon J, Hong F, Ruzek M, Padley RJ. Safety,
Tolerability, and Pharmacodynamics of ABT-122, a Dual TNF- and IL-17-Targeted
Dual Variable Domain (DVD)-IgTM in Subjects with Rheumatoid Arthritis
[abstract]. Arthritis Rheumatol. 2015;
67 (suppl 10). http://acrabstracts.org/abstract/safety-tolerability-and-pharmacodynamics-of-abt-122-a-dual-tnf-and-il-17-targeted-dual-variable-domain-dvd-igtm-in-subjects-with-rheumatoid-arthritis/.
Accessed November 20, 2015.
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