Thursday, December 27, 2012

Secukinumab at the ACR 2012 in Washington

Secukinumab is an Anti-Il17a Monoclonal Antibody.  

X. Baraliakos and colleagues tested secukinumab (IL-17A inhibition) in a proof-of-concept (PoC) trial and showed via MRI, that secukinumab may reduce spinal inflammation (Abstract No. 574). Conclusion: “This exploratory MRI analysis shows that the IL-17 inhibitor secukinumab may reduce spinal inflammation and this effect may be sustained for up to 24 months using a lower dose in the maintenance compared to induction phase. …”.

D. L. Baeten and colleagues presented another study on secukinumab in ankylosing spondylitis (Abstract No. 2225): “Improvement in Signs and Symptoms of Active Ankylosing Spondylitis Following Treatment with Anti-Interleukin (IL)-17A Monoclonal Antibody Secukinumab Are Paralleled by Reductions in Acute Phase Markers and Inflammatory Markers S100A8 and A9 (Calgranulin A and B)”. It’s a dose finding study with only 30 patients in a multicenter setting. Conclusion: “In this trial of secukinumab in AS, exploratory analyses of selected inflammatory markers suggest that secukinumab reduces CRP, S100A8 and S100A9, but only S100A8/9 reductions appear to correlate with clinical responses at Wk 6. …”.

There are some promising results, but secukinumab still has a long way to go.

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