Thursday, November 29, 2018

Caffeine Stimulates Hepatic Lipid Metabolism

Recently I’ve read a short article in German concerning coffee and liver cirrhosis [1]. In this short article, it was believed that "coffee has a favorable impact on metabolic syndrome, fatty liver disease, and non-alcoholic fatty acid inflammation [NASH], and even counteracts obesity and overall mortality." And: "The positive effects appear to be primarily in caffeine-containing filter coffee." I recall an earlier Swedish study that certain lipids were retained by the paper filter as they compared the Swedish way of brewing coffee pressing the fluid through a mesh in a jug with the method of retaining the ground coffee in a paper filter in terms of hypercholesterolemia.

There has been a study on mice published in the journal Hepatology [2]. According to the authors of this study “caffeine has a potent effect in lowering levels of hepatic lipids by activation of autophagy in cell culture and in vivo”. “Because there still are no approved drug therapies for NAFLD [nonalcoholic fatty liver disease] understanding the mechanistic basis of action of natural dietary products such as caffeine offers further insight into developing drugs for the prevention and treatment of NAFLD.”

D.M. Torres and S.A. Harrison had written on: Is it time to write a prescription for coffee? Coffee and liver disease [3]. “Reduced hepatic fibrosis seems to be specific to caffeinated coffee and does not seem to be shared by other caffeinated beverages.” “There are approximately 1000 substances in coffee, including caffeine, diterphenoic alcohols, potassium, niacin, magnesium, and the anti-oxidants chlorogenic acid (CGA) and tocopherols.”

Coffee that contains caffeine and has been brewed with the help of filter paper may help in the prevention and treatment of nonalcoholic fatty liver disease and other diseases.

PS. The best way to brew coffee still is manually using filter paper in a porcelain filter cone - just like Mum & Dad were brewing coffee in 50ies or 60ies.



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